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Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here we r...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880455/ https://www.ncbi.nlm.nih.gov/pubmed/18849971 http://dx.doi.org/10.1038/nchembio.117 |