Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor Exploits Competition between L-Arginine Ligands and Resident Arginine Residues

An elegantly simple and probably ancient molecular mechanism of allostery is described for the Escherichia coli arginine repressor ArgR, the master feedback regulator of transcription in L-arginine metabolism. Molecular dynamics simulations with ArgRC, the hexameric domain that binds L-arginine with...

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Detalles Bibliográficos
Autores principales: Strawn, Rebecca, Melichercik, Milan, Green, Michael, Stockner, Thomas, Carey, Jannette, Ettrich, Rüdiger
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880562/
https://www.ncbi.nlm.nih.gov/pubmed/20532206
http://dx.doi.org/10.1371/journal.pcbi.1000801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880562/
https://www.ncbi.nlm.nih.gov/pubmed/20532206
http://dx.doi.org/10.1371/journal.pcbi.1000801

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