Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs

Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood. We used multiple approaches to demonstrate a critical requirement for ergosterol in vacuolar H(+)-ATPase function, which is...

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Detalles Bibliográficos
Autores principales: Zhang, Yong-Qiang, Gamarra, Soledad, Garcia-Effron, Guillermo, Park, Steven, Perlin, David S., Rao, Rajini
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880581/
https://www.ncbi.nlm.nih.gov/pubmed/20532216
http://dx.doi.org/10.1371/journal.ppat.1000939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880581/
https://www.ncbi.nlm.nih.gov/pubmed/20532216
http://dx.doi.org/10.1371/journal.ppat.1000939

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