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Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs
Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood. We used multiple approaches to demonstrate a critical requirement for ergosterol in vacuolar H(+)-ATPase function, which is...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880581/ https://www.ncbi.nlm.nih.gov/pubmed/20532216 http://dx.doi.org/10.1371/journal.ppat.1000939 |