Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases

Activation of androgen receptor (AR) may play a role in the development of castration resistant prostate cancer. Two intracellular tyrosine kinases, Ack1 (activated cdc42-associated kinase) and Src, phosphorylate and enhance AR activity and promote prostate xenograft tumor growth in castrated animal...

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Detalles Bibliográficos
Autores principales: Liu, Yuanbo, Karaca, Mehmet, Zhang, Zhentao, Gioeli, Daniel, Earp, H. Shelton, Whang, Young E.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880659/
https://www.ncbi.nlm.nih.gov/pubmed/20383201
http://dx.doi.org/10.1038/onc.2010.103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880659/
https://www.ncbi.nlm.nih.gov/pubmed/20383201
http://dx.doi.org/10.1038/onc.2010.103

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