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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

The Myc oncogene regulates the expression of multiple components of the protein synthetic machinery, including ribosomal proteins, initiation factors of translation, Pol III, and rDNA1,2. An outstanding question is whether and how increasing the cellular protein synthesis capacity can affect the mul...

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Detalles Bibliográficos
Autores principales: Barna, Maria, Pusic, Aya, Zollo, Ornella, Costa, Maria, Kondrashov, Nadya, Rego, Eduardo, Rao, Pulivarthi H, Ruggero, Davide
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880952/
https://www.ncbi.nlm.nih.gov/pubmed/19011615
http://dx.doi.org/10.1038/nature07449