Cargando…
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
The Myc oncogene regulates the expression of multiple components of the protein synthetic machinery, including ribosomal proteins, initiation factors of translation, Pol III, and rDNA1,2. An outstanding question is whether and how increasing the cellular protein synthesis capacity can affect the mul...
Autores principales: | Barna, Maria, Pusic, Aya, Zollo, Ornella, Costa, Maria, Kondrashov, Nadya, Rego, Eduardo, Rao, Pulivarthi H, Ruggero, Davide |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880952/ https://www.ncbi.nlm.nih.gov/pubmed/19011615 http://dx.doi.org/10.1038/nature07449 |
Ejemplares similares
-
IBTK Haploinsufficiency Affects the Tumor Microenvironment of Myc-Driven Lymphoma in E-myc Mice
por: Vecchio, Eleonora, et al.
Publicado: (2020) -
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential
por: Madgwick, Suzanne, et al.
Publicado: (2022) -
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice
por: Grieb, Brian C., et al.
Publicado: (2016) -
MYC Oncogene Contributions to Release of Cell Cycle Brakes
por: García-Gutiérrez, Lucía, et al.
Publicado: (2019) -
Oncogenic MYC amplifies mitotic perturbations
por: Littler, Samantha, et al.
Publicado: (2019)