Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

BACKGROUND: Anti-IL-21R antibodies are potential therapeutics for the treatment of autoimmune diseases. This study evaluated correlations between the pharmacodynamic (PD) activity, pharmacokinetics, and anti-product antibody responses of human anti-IL-21R antibodies Ab-01 and Ab-02 following IV admi...

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Detalles Bibliográficos
Autores principales: Vugmeyster, Yulia, Allen, Scott, Szklut, Pamela, Bree, Andrea, Ryan, Mark, Ma, Margery, Spaulding, Vikki, Young, Deborah, Guay, Heath, Bloom, Laird, Leach, Michael W, O'Toole, Margot, Adkins, Karissa
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880981/
https://www.ncbi.nlm.nih.gov/pubmed/20420683
http://dx.doi.org/10.1186/1479-5876-8-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880981/
https://www.ncbi.nlm.nih.gov/pubmed/20420683
http://dx.doi.org/10.1186/1479-5876-8-41

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