Hypoxia Activates the K-Ras Proto-Oncogene to Stimulate Angiogenesis and Inhibit Apoptosis in Colon Cancer Cells

The KRAS proto-oncogene plays a key role in the development of many human tumors and is commonly activated by somatic mutation or signaling through specific growth factor receptors. However, the interaction between the micro-environment and K-ras activity has not been defined. Hypoxia invariably dev...

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Detalles Bibliográficos
Autores principales: Zeng, Min, Kikuchi, Hirotoshi, Pino, Maria S., Chung, Daniel C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881039/
https://www.ncbi.nlm.nih.gov/pubmed/20532039
http://dx.doi.org/10.1371/journal.pone.0010966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881039/
https://www.ncbi.nlm.nih.gov/pubmed/20532039
http://dx.doi.org/10.1371/journal.pone.0010966

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