Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes

BACKGROUND: Transcription of HIV-1 cDNA prior to, or in the absence of, integration leads to synthesis of all classes of viral RNA transcripts. Yet only a limited range of viral proteins, including Nef, are translated in this context. Nef expression from unintegrated HIV-1 DNA has been shown to redu...

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Detalles Bibliográficos
Autores principales: Sloan, Richard D, Donahue, Daniel A, Kuhl, Björn D, Bar-Magen, Tamara, Wainberg, Mark A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881062/
https://www.ncbi.nlm.nih.gov/pubmed/20465832
http://dx.doi.org/10.1186/1742-4690-7-44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881062/
https://www.ncbi.nlm.nih.gov/pubmed/20465832
http://dx.doi.org/10.1186/1742-4690-7-44

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