Multiple Loss-of-Function Mechanisms Contribute to SCN5A-Related Familial Sick Sinus Syndrome

BACKGROUND: To identify molecular mechanisms underlying SCN5A-related sick sinus syndrome (SSS), a rare type of SSS, in parallel experiments we elucidated the electrophysiological properties and the cell surface localization of thirteen human Na(v)1.5 (hNa(v)1.5) mutant channels previously linked to...

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Detalles Bibliográficos
Autores principales: Gui, Junhong, Wang, Tao, Jones, Richard P. O., Trump, Dorothy, Zimmer, Thomas, Lei, Ming
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881866/
https://www.ncbi.nlm.nih.gov/pubmed/20539757
http://dx.doi.org/10.1371/journal.pone.0010985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881866/
https://www.ncbi.nlm.nih.gov/pubmed/20539757
http://dx.doi.org/10.1371/journal.pone.0010985

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