A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage

A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed...

Descripción completa

Detalles Bibliográficos
Autores principales: Shinya, Kyoko, Makino, Akiko, Hatta, Masato, Watanabe, Shinji, Kim, Jin Hyun, Kawaoka, Yoshihiro
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2010
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881941/
https://www.ncbi.nlm.nih.gov/pubmed/20130132
http://dx.doi.org/10.1099/vir.0.018572-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881941/
https://www.ncbi.nlm.nih.gov/pubmed/20130132
http://dx.doi.org/10.1099/vir.0.018572-0

Ejemplares similares