A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage

A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed...

Descripción completa

Detalles Bibliográficos
Autores principales: Shinya, Kyoko, Makino, Akiko, Hatta, Masato, Watanabe, Shinji, Kim, Jin Hyun, Kawaoka, Yoshihiro
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2010
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881941/
https://www.ncbi.nlm.nih.gov/pubmed/20130132
http://dx.doi.org/10.1099/vir.0.018572-0
_version_ 1782182153739567104
author Shinya, Kyoko
Makino, Akiko
Hatta, Masato
Watanabe, Shinji
Kim, Jin Hyun
Kawaoka, Yoshihiro
author_facet Shinya, Kyoko
Makino, Akiko
Hatta, Masato
Watanabe, Shinji
Kim, Jin Hyun
Kawaoka, Yoshihiro
author_sort Shinya, Kyoko
collection PubMed
description A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage.
format Text
id pubmed-2881941
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Society for General Microbiology
record_format MEDLINE/PubMed
spelling pubmed-28819412011-06-01 A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage Shinya, Kyoko Makino, Akiko Hatta, Masato Watanabe, Shinji Kim, Jin Hyun Kawaoka, Yoshihiro J Gen Virol Animal A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage. Society for General Microbiology 2010-06 /pmc/articles/PMC2881941/ /pubmed/20130132 http://dx.doi.org/10.1099/vir.0.018572-0 Text en Copyright © 2010, SGM
spellingShingle Animal
Shinya, Kyoko
Makino, Akiko
Hatta, Masato
Watanabe, Shinji
Kim, Jin Hyun
Kawaoka, Yoshihiro
A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
title A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
title_full A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
title_fullStr A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
title_full_unstemmed A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
title_short A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
title_sort mutation in h5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881941/
https://www.ncbi.nlm.nih.gov/pubmed/20130132
http://dx.doi.org/10.1099/vir.0.018572-0
work_keys_str_mv AT shinyakyoko amutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT makinoakiko amutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT hattamasato amutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT watanabeshinji amutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT kimjinhyun amutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT kawaokayoshihiro amutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT shinyakyoko mutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT makinoakiko mutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT hattamasato mutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT watanabeshinji mutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT kimjinhyun mutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage
AT kawaokayoshihiro mutationinh5haemagglutininthatconferredhumanreceptorrecognitionisnotmaintainedstablyduringduckpassage

Ejemplares similares