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A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage

A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed...

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Detalles Bibliográficos
Autores principales:	Shinya, Kyoko, Makino, Akiko, Hatta, Masato, Watanabe, Shinji, Kim, Jin Hyun, Kawaoka, Yoshihiro
Formato:	Texto
Lenguaje:	English
Publicado:	Society for General Microbiology 2010
Materias:	Animal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881941/ https://www.ncbi.nlm.nih.gov/pubmed/20130132 http://dx.doi.org/10.1099/vir.0.018572-0

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