Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1

Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inhibitors of human 17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD 1) for the treatment of breast cancer or endometriosis, novel substances based on 15-substituted estrone were validated. We checked...

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Detalles Bibliográficos
Autores principales: Möller, Gabriele, Husen, Bettina, Kowalik, Dorota, Hirvelä, Leena, Plewczynski, Dariusz, Rychlewski, Leszek, Messinger, Josef, Thole, Hubert, Adamski, Jerzy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882332/
https://www.ncbi.nlm.nih.gov/pubmed/20544026
http://dx.doi.org/10.1371/journal.pone.0010969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882332/
https://www.ncbi.nlm.nih.gov/pubmed/20544026
http://dx.doi.org/10.1371/journal.pone.0010969

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