A genome-wide RNA interference screen reveals an essential CREB3L2/ATF5/MCL1 survival pathway in malignant glioma with therapeutic implications

Activating transcription factor 5 (ATF5) is highly expressed in malignant glioma and plays an important role in promoting cell survival. Here we perform a genome-wide RNA interference (RNAi) screen to identify transcriptional regulators of ATF5. Our results reveal an essential survival pathway in ma...

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Detalles Bibliográficos
Autores principales: Sheng, Zhi, Li, Li, Zhu, Lihua J., Smith, Thomas W., Demers, Andrea, Ross, Alonzo H., Moser, Richard P., Green, Michael R.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882506/
https://www.ncbi.nlm.nih.gov/pubmed/20495567
http://dx.doi.org/10.1038/nm.2158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882506/
https://www.ncbi.nlm.nih.gov/pubmed/20495567
http://dx.doi.org/10.1038/nm.2158

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