A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

Type II topoisomerases are required for the management of DNA tangles and supercoils1, and are targets of clinical antibiotics and anti-cancer agents2. These enzymes catalyze the ATP-dependent passage of one DNA duplex (the transport or T-segment) through a transient, double-stranded break in anothe...

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Detalles Bibliográficos
Autores principales: Schmidt, Bryan H., Burgin, Alex B., Deweese, Joseph E., Osheroff, Neil, Berger, James M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882514/
https://www.ncbi.nlm.nih.gov/pubmed/20485342
http://dx.doi.org/10.1038/nature08974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882514/
https://www.ncbi.nlm.nih.gov/pubmed/20485342
http://dx.doi.org/10.1038/nature08974

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