ERK activation drives intestinal tumorigenesis in Apc(min/)(+) mice

TLR signaling is essential for intestinal tumorigenesis in Apc(min/)(+) mice, but the mechanisms by which this protein enhances tumor growth are unknown. Here we show that the Microflora-MyD88-ERK signaling in intestinal epithelial cells (IEC) promotes tumorigenesis by increasing the stability of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Sung Hee, Hu, Li-Li, Gonzalez-Navajas, Jose, Seo, Geom Seog, Shen, Carol, Brick, Jonathan, Herdman, Scott, Varki, Nissi, Corr, Maripat, Lee, Jongdae, Raz, Eyal
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882530/
https://www.ncbi.nlm.nih.gov/pubmed/20473309
http://dx.doi.org/10.1038/nm.2143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882530/
https://www.ncbi.nlm.nih.gov/pubmed/20473309
http://dx.doi.org/10.1038/nm.2143

Ejemplares similares