Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

T cell selection and maturation in the thymus depends on the interactions between T cell receptors (TCRs) and different self-peptide–major histocompatibility complex (pMHC) molecules. We show that the affinity of the OT-I TCR for its endogenous positively selecting ligands, Catnb-H-2K(b) and Cappa1-...

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Detalles Bibliográficos
Autores principales: Juang, Jeremy, Ebert, Peter J.R., Feng, Dan, Garcia, K. Christopher, Krogsgaard, Michelle, Davis, Mark M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882826/
https://www.ncbi.nlm.nih.gov/pubmed/20457759
http://dx.doi.org/10.1084/jem.20092170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882826/
https://www.ncbi.nlm.nih.gov/pubmed/20457759
http://dx.doi.org/10.1084/jem.20092170

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