Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children

BACKGROUND: Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological features of filaggrin haploinsufficiency have not been clearly defined. OBJECTIVES: This study investigated the genotype–phenotype association betwe...

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Detalles Bibliográficos
Autores principales: Brown, SJ, Relton, CL, Liao, H, Zhao, Y, Sandilands, A, McLean, WHI, Cordell, HJ, Reynolds, NJ
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883069/
https://www.ncbi.nlm.nih.gov/pubmed/19681860
http://dx.doi.org/10.1111/j.1365-2133.2009.09339.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883069/
https://www.ncbi.nlm.nih.gov/pubmed/19681860
http://dx.doi.org/10.1111/j.1365-2133.2009.09339.x

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