Type 2 Diabetes Susceptibility Gene Expression in Normal or Diabetic Sorted Human Alpha and Beta Cells: Correlations with Age or BMI of Islet Donors

BACKGROUND: Genome-wide association studies have identified susceptibility genes for development of type 2 diabetes. We aimed to examine whether a subset of these (comprising FTO, IDE, KCNJ11, PPARG and TCF7L2) were transcriptionally restricted to or enriched in human beta cells by sorting islet cel...

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Detalles Bibliográficos
Autores principales: Kirkpatrick, Clare L., Marchetti, Piero, Purrello, Francesco, Piro, Salvatore, Bugliani, Marco, Bosco, Domenico, de Koning, Eelco J. P., Engelse, Marten A., Kerr-Conte, Julie, Pattou, François, Wollheim, Claes B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883550/
https://www.ncbi.nlm.nih.gov/pubmed/20548773
http://dx.doi.org/10.1371/journal.pone.0011053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883550/
https://www.ncbi.nlm.nih.gov/pubmed/20548773
http://dx.doi.org/10.1371/journal.pone.0011053

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