Evidence That SOX2 Overexpression Is Oncogenic in the Lung

BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL FINDINGS: We show that SOX2 is overexpressed in human squamous cell lung tumors and some adenocarcinomas. We ha...

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Detalles Bibliográficos
Autores principales: Lu, Yun, Futtner, Christopher, Rock, Jason R., Xu, Xia, Whitworth, Walter, Hogan, Brigid L. M., Onaitis, Mark W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883553/
https://www.ncbi.nlm.nih.gov/pubmed/20548776
http://dx.doi.org/10.1371/journal.pone.0011022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883553/
https://www.ncbi.nlm.nih.gov/pubmed/20548776
http://dx.doi.org/10.1371/journal.pone.0011022

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