Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations

The tripartite complex AcrAB-TolC is the major efflux system in Escherichia coli. It extrudes a wide spectrum of noxious compounds out of the bacterium, including many antibiotics. Its active part, the homotrimeric transporter AcrB, is responsible for the selective binding of substrates and energy t...

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Detalles Bibliográficos
Autores principales: Schulz, Robert, Vargiu, Attilio V., Collu, Francesca, Kleinekathöfer, Ulrich, Ruggerone, Paolo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883587/
https://www.ncbi.nlm.nih.gov/pubmed/20548943
http://dx.doi.org/10.1371/journal.pcbi.1000806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883587/
https://www.ncbi.nlm.nih.gov/pubmed/20548943
http://dx.doi.org/10.1371/journal.pcbi.1000806

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