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Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations
The tripartite complex AcrAB-TolC is the major efflux system in Escherichia coli. It extrudes a wide spectrum of noxious compounds out of the bacterium, including many antibiotics. Its active part, the homotrimeric transporter AcrB, is responsible for the selective binding of substrates and energy t...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883587/ https://www.ncbi.nlm.nih.gov/pubmed/20548943 http://dx.doi.org/10.1371/journal.pcbi.1000806 |