Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

BACKGROUND: Cancer cells are highly dependent on glycolysis. Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer cells over normal cells, and to examine the underlying mechanisms. METHODS: Represen...

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Detalles Bibliográficos
Autores principales: Madhok, B M, Yeluri, S, Perry, S L, Hughes, T A, Jayne, D G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883702/
https://www.ncbi.nlm.nih.gov/pubmed/20485289
http://dx.doi.org/10.1038/sj.bjc.6605701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883702/
https://www.ncbi.nlm.nih.gov/pubmed/20485289
http://dx.doi.org/10.1038/sj.bjc.6605701

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