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Structural and mechanistic basis for a novel mode of glycosyltransferase inhibition
Glycosyltransferases are carbohydrate-active enzymes with essential roles in numerous important biological processes. We have developed a novel donor analogue for galactosyltransferases which locks a representative target enzyme in a catalytically inactive conformation, thus almost completely abolis...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883747/ https://www.ncbi.nlm.nih.gov/pubmed/20364127 http://dx.doi.org/10.1038/nchembio.343 |