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Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB()
Liver injury associated with exposure to therapeutic agents that undergo hepatic metabolism can involve the formation of reactive metabolites. These may cause redox perturbation which can result in oxidative stress as well as protein modification leading to activation or inhibition of cellular trans...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884179/ https://www.ncbi.nlm.nih.gov/pubmed/20416283 http://dx.doi.org/10.1016/j.bcp.2010.04.004 |