mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated with schizophrenia. mGluR5 plays an important role in both long term potentiation (LTP) and long term depression (LT...

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Detalles Bibliográficos
Autores principales: Ayala, Jennifer E., Chen, Yelin, Banko, Jessica L., Sheffler, Douglas J., Williams, Richard, Telk, Alexandra N., Watson, Noreen L., Xiang, Zixiu, Zhang, Yongqin, Jones, Paulianda J., Lindsley, Craig W., Olive, M. Foster, Conn, P. Jeffrey
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884290/
https://www.ncbi.nlm.nih.gov/pubmed/19295507
http://dx.doi.org/10.1038/npp.2009.30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884290/
https://www.ncbi.nlm.nih.gov/pubmed/19295507
http://dx.doi.org/10.1038/npp.2009.30

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