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Improving draft assemblies by iterative mapping and assembly of short reads to eliminate gaps

Advances in sequencing technology allow genomes to be sequenced at vastly decreased costs. However, the assembled data frequently are highly fragmented with many gaps. We present a practical approach that uses Illumina sequences to improve draft genome assemblies by aligning sequences against contig...

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Detalles Bibliográficos
Autores principales: Tsai, Isheng J, Otto, Thomas D, Berriman, Matthew
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884544/
https://www.ncbi.nlm.nih.gov/pubmed/20388197
http://dx.doi.org/10.1186/gb-2010-11-4-r41