A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species

The V protein of the paramyxovirus Nipah virus (NiV) has been shown to antagonize the interferon (IFN) response in human cells via sequestration of STAT1 and STAT2. This study describes a mutant of the NiV V protein, referred to as V(AAHL), that is unable to antagonize IFN signalling and demonstrate...

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Detalles Bibliográficos
Autores principales: Hagmaier, Kathrin, Stock, Nicola, Goodbourn, Steve, Wang, Lin-Fa, Randall, Richard
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2006
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884973/
https://www.ncbi.nlm.nih.gov/pubmed/17098981
http://dx.doi.org/10.1099/vir.0.82261-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884973/
https://www.ncbi.nlm.nih.gov/pubmed/17098981
http://dx.doi.org/10.1099/vir.0.82261-0

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