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A short treatment of cells with the lanthanide ions La(3+), Ce(3+), Pr(3+) or Nd(3+) changes the cellular chemistry into a state in which RNA replication of flaviviruses is specifically blocked without interference with host-cell multiplication
Alpha- and flaviviruses contain class II fusion proteins, which form ion-permeable pores in the target membrane during virus entry. The pores generated during entry of the alphavirus Semliki Forest virus have been shown previously to be blocked by lanthanide ions. Here, analyses of the influence of...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Society for General Microbiology
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884975/ https://www.ncbi.nlm.nih.gov/pubmed/17947525 http://dx.doi.org/10.1099/vir.0.83146-0 |