PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response

The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates apoptosis and IFN synthesis. To determine the...

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Detalles Bibliográficos
Autores principales: Barry, Gerald, Breakwell, Lucy, Fragkoudis, Rennos, Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, Julio, Kohl, Alain, Fazakerley, John K.
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2009
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885058/
https://www.ncbi.nlm.nih.gov/pubmed/19264662
http://dx.doi.org/10.1099/vir.0.007336-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885058/
https://www.ncbi.nlm.nih.gov/pubmed/19264662
http://dx.doi.org/10.1099/vir.0.007336-0

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