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The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model

BACKGROUND: Androgens bind to the androgen receptor (AR) in prostate cells and are essential survival factors for healthy prostate epithelium. Most untreated prostate cancers retain some dependence upon the AR and respond, at least transiently, to androgen ablation therapy. However, the relationship...

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Detalles Bibliográficos
Autores principales: Eikenberry, Steffen E, Nagy, John D, Kuang, Yang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885348/
https://www.ncbi.nlm.nih.gov/pubmed/20406442
http://dx.doi.org/10.1186/1745-6150-5-24