A new method to detect loss of heterozygosity using cohort heterozygosity comparisons

BACKGROUND: Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA samples. However, for many archival sam...

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Detalles Bibliográficos
Autores principales: Green, Michael R, Jardine, Paul, Wood, Peter, Wellwood, Jeremy, Lea, Rod A, Marlton, Paula, Griffiths, Lyn R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885361/
https://www.ncbi.nlm.nih.gov/pubmed/20462409
http://dx.doi.org/10.1186/1471-2407-10-195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885361/
https://www.ncbi.nlm.nih.gov/pubmed/20462409
http://dx.doi.org/10.1186/1471-2407-10-195

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