Precursor of Advanced Glycation End Products Mediates ER-Stress-Induced Caspase-3 Activation of Human Dermal Fibroblasts through NAD(P)H Oxidase 4

BACKGROUND: The precursor for advanced glycation end products, 3-deoxyglucosone (3DG) is highly upregulated in skin explants of diabetic cutaneous wounds, and has been shown to negatively impact dermal fibroblasts, which are crucial in wound remodeling. 3DG induces apoptosis however; the mechanisms...

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Detalles Bibliográficos
Autores principales: Loughlin, Danielle T., Artlett, Carol M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885413/
https://www.ncbi.nlm.nih.gov/pubmed/20559423
http://dx.doi.org/10.1371/journal.pone.0011093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885413/
https://www.ncbi.nlm.nih.gov/pubmed/20559423
http://dx.doi.org/10.1371/journal.pone.0011093

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