Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor

The rational design of amyloid oligomer inhibitors is yet an unmet drug development need. Previous studies have identified the role of tryptophan in amyloid recognition, association and inhibition. Furthermore, tryptophan was ranked as the residue with highest amyloidogenic propensity. Other studies...

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Detalles Bibliográficos
Autores principales: Scherzer-Attali, Roni, Pellarin, Riccardo, Convertino, Marino, Frydman-Marom, Anat, Egoz-Matia, Nirit, Peled, Sivan, Levy-Sakin, Michal, Shalev, Deborah E., Caflisch, Amedeo, Gazit, Ehud, Segal, Daniel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885425/
https://www.ncbi.nlm.nih.gov/pubmed/20559435
http://dx.doi.org/10.1371/journal.pone.0011101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885425/
https://www.ncbi.nlm.nih.gov/pubmed/20559435
http://dx.doi.org/10.1371/journal.pone.0011101

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