Cargando…

Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor

The rational design of amyloid oligomer inhibitors is yet an unmet drug development need. Previous studies have identified the role of tryptophan in amyloid recognition, association and inhibition. Furthermore, tryptophan was ranked as the residue with highest amyloidogenic propensity. Other studies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scherzer-Attali, Roni, Pellarin, Riccardo, Convertino, Marino, Frydman-Marom, Anat, Egoz-Matia, Nirit, Peled, Sivan, Levy-Sakin, Michal, Shalev, Deborah E., Caflisch, Amedeo, Gazit, Ehud, Segal, Daniel
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885425/ https://www.ncbi.nlm.nih.gov/pubmed/20559435 http://dx.doi.org/10.1371/journal.pone.0011101

Ejemplares similares

Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies
por: Shaltiel-Karyo, Ronit, et al.
Publicado: (2010)

Orally Administrated Cinnamon Extract Reduces β-Amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer's Disease Animal Models
por: Frydman-Marom, Anat, et al.
Publicado: (2011)

Total proteome turbidity assay for tracking global protein aggregation in the natural cellular environment
por: Shmueli, Merav D., et al.
Publicado: (2017)

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies
por: Bram, Yaron, et al.
Publicado: (2014)

Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids
por: KrishnaKumar, V. Guru, et al.
Publicado: (2018)

Naphthoquinone Tryptophan Hybrids: A Promising Small Molecule Scaffold for Mitigating Aggregation of Amyloidogenic Proteins and Peptides
por: Viswanathan, Guru KrishnaKumar, et al.
Publicado: (2019)

Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model
por: Bram, Yaron, et al.
Publicado: (2017)

Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation
por: Peled, Sivan, et al.
Publicado: (2017)

Inhibitory Effect of Naphthoquinone-Tryptophan Hybrid towards Aggregation of PAP f39 Semen Amyloid
por: Viswanathan, Guru KrishnaKumar, et al.
Publicado: (2018)

Therapeutic Effects of Melatonin Receptor Agonists on Sleep and Comorbid Disorders
por: Laudon, Moshe, et al.
Publicado: (2014)

Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity
por: Paul, Ashim, et al.
Publicado: (2020)

The Effect of Chemical Chaperones on the Assembly and Stability of HIV-1 Capsid Protein
por: Lampel, Ayala, et al.
Publicado: (2013)

Dynamic microfluidic control of supramolecular peptide self-assembly
por: Arnon, Zohar A., et al.
Publicado: (2016)

A Data-Driven Strategy for Identifying Individuals Resistant to SARS-CoV-2 Virus under In-Household Exposure
por: Hen Gabzi, Roni, et al.
Publicado: (2022)

Non-Covalent Binding of Tripeptides-Containing Tryptophan to Polynucleotides and Photochemical Deamination of Modified Tyrosine to Quinone Methide Leading to Covalent Attachment
por: Erben, Antonija, et al.
Publicado: (2021)

Quinone-Amino Acid Conjugates Targeting Leishmania Amino Acid Transporters
por: Prati, Federica, et al.
Publicado: (2014)

Quinone binding site in a type VI sulfide:quinone oxidoreductase
por: Miklovics, Nikolett, et al.
Publicado: (2022)

The Influence of Chemical Chaperones on Enzymatic Activity under Thermal and Chemical Stresses: Common Features and Variation among Diverse Chemical Families
por: Levy-Sakin, Michal, et al.
Publicado: (2014)

The Highs and Lows of P Supply in Medical Cannabis: Effects on Cannabinoids, the Ionome, and Morpho-Physiology
por: Shiponi, Sivan, et al.
Publicado: (2021)

The Free Energy Landscape of Small Molecule Unbinding
por: Huang, Danzhi, et al.
Publicado: (2011)

Quinones as Neuroprotective Agents
por: Cores, Ángel, et al.
Publicado: (2023)

Reactivities of Quinone Methides versus o-Quinones in Catecholamine Metabolism and Eumelanin Biosynthesis
por: Sugumaran, Manickam
Publicado: (2016)

Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome
por: Shmueli, Merav D., et al.
Publicado: (2014)

Mutation at the entrance of the quinone cavity severely disrupts quinone binding in respiratory complex I
por: Yi, Jason Tae, et al.
Publicado: (2023)

Dynamics in COVID-19 symptoms during different waves of the pandemic among children infected with SARS-CoV-2 in the ambulatory setting
por: Ben-Tov, Amir, et al.
Publicado: (2022)

Visual Expressions of Children’s Strengths, Difficulties and Wishes in Person Picking an Apple from a Tree Drawings among Preschoolers Living in Areas of Persistent Political Violence
por: Bat Or, Michal, et al.
Publicado: (2022)

Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial
por: Wade, Alan G, et al.
Publicado: (2014)

An Outbreak of Parvovirus B19 in Israel
por: Patalon, Tal, et al.
Publicado: (2023)

The Domestication of ortho-Quinone Methides
por: Bai, Wen-Ju, et al.
Publicado: (2014)

High-Resolution Visualisation of the States and Pathways Sampled in Molecular Dynamics Simulations
por: Blöchliger, Nicolas, et al.
Publicado: (2014)

Unsupervised Methods for Detection of Neural States: Case Study of Hippocampal-Amygdala Interactions
por: Cocina, Francesco, et al.
Publicado: (2021)

Spiking burstiness and working memory in the human medial temporal lobe
por: Cocina, Francesco, et al.
Publicado: (2022)

Using Expression Profiles of Caenorhabditis elegans Neurons To Identify Genes That Mediate Synaptic Connectivity
por: Baruch, Leehod, et al.
Publicado: (2008)

Structural Insights into the Folding Defects of Oncogenic pVHL Lead to Correction of Its Function In Vitro
por: Shmueli, Merav D., et al.
Publicado: (2013)

Attempted characterisation of phenanthrene-4,5-quinone and electrochemical synthesis of violanthrone-16,17-quinone. How does the stability of bay quinones correlate with structural and electronic parameters?
por: Wilkinson, Dylan, et al.
Publicado: (2020)

Riboflavin compounds show NAD(P)H dependent quinone oxidoreductase-like quinone reducing activity
por: Nagase, Midori, et al.
Publicado: (2023)

Synthetic Strategies to Terpene Quinones/Hydroquinones
por: Gordaliza, Marina
Publicado: (2012)

Production and Radioprotective Effects of Pyrroloquinoline Quinone
por: Xiong, Xiang-Hua, et al.
Publicado: (2011)

Effects of several quinones on insulin aggregation
por: Gong, Hao, et al.
Publicado: (2014)

The Emergence of Quinone Methides in Asymmetric Organocatalysis
por: Caruana, Lorenzo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5t8pq2fjnosk9j6mtkrevv8l0h