Cargando…

HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia

BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the expression of a diverse range of genes. The purpose of this study was t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mowat, Freya M., Luhmann, Ulrich F. O., Smith, Alexander J., Lange, Clemens, Duran, Yanai, Harten, Sarah, Shukla, Deepa, Maxwell, Patrick H., Ali, Robin R., Bainbridge, James W. B.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885428/ https://www.ncbi.nlm.nih.gov/pubmed/20559438 http://dx.doi.org/10.1371/journal.pone.0011103

Ejemplares similares

Cloning and expression analysis of two distinct HIF-alpha isoforms – gcHIF-1alpha and gcHIF-4alpha – from the hypoxia-tolerant grass carp, Ctenopharyngodon idellus
por: Law, Sheran HW, et al.
Publicado: (2006)

Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia
por: Villacampa, Pilar, et al.
Publicado: (2019)

The Study of Expression of Hypoxia-Inducible Factor-1 Alpha (HIF-1 Alpha) and Hypoxia-Inducible Factor-2 Alpha (HIF-2 Alpha) in Oral Squamous Cell Carcinoma: An Immunohistochemical Study
por: Mahapatra, Niva, et al.
Publicado: (2023)

Oxygen-dependent and -independent regulation of HIF-1alpha.
por: Chun, Yang-Sook, et al.
Publicado: (2002)

Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes
por: Inoue, Hiroaki, et al.
Publicado: (2015)

Hypoxic Regulation of VEGF, HIF-1(alpha) in Coronary Collaterals Development
por: Sung, Ki Chul, et al.
Publicado: (2005)

Hypoxia–Induced Cytotoxic Drug Resistance in Osteosarcoma Is Independent of HIF-1Alpha
por: Adamski, Jennifer, et al.
Publicado: (2013)

HIF-1alpha Deficiency Attenuates the Cardiomyogenesis of Mouse Embryonic Stem Cells
por: Kudová, Jana, et al.
Publicado: (2016)

Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha
por: Fitzpatrick, Susan F., et al.
Publicado: (2018)

(H)IF applicable: promotion of neurogenesis by induced HIF-2 signalling after ischaemia
por: Leu, Tristan, et al.
Publicado: (2021)

Comparative study of antioxidants as cancer preventives through inhibition of HIF-1 alpha activity
por: Upadhyay, Jyoti, et al.
Publicado: (2009)

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity
por: Kuo, Ching-Ying, et al.
Publicado: (2016)

HIF-1alpha and infectious diseases: a new frontier for the development of new therapies
por: dos Santos, Sânia Alves, et al.
Publicado: (2017)

Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
por: Menendez-Montes, Ivan, et al.
Publicado: (2021)

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study
por: Daponte, Alexandros, et al.
Publicado: (2008)

HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells
por: Arreola, Alexandra, et al.
Publicado: (2014)

HIF1-Alpha Expression Predicts Survival of Patients with Squamous Cell Carcinoma of the Oral Cavity
por: dos Santos, Marcelo, et al.
Publicado: (2012)

Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications
por: Cao, Dan, et al.
Publicado: (2009)

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma
por: Leppänen, Joni, et al.
Publicado: (2018)

HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor
por: Fillies, Thomas, et al.
Publicado: (2005)

HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?
por: Nuessle, Simone, et al.
Publicado: (2020)

Hypoxia-inducible factor (HIF1alpha) inhibition modulates cumulus cell function and affects bovine oocyte maturation in vitro
por: Turhan, Aslihan, et al.
Publicado: (2020)

An Association Study between Hypoxia Inducible Factor-1alpha (HIF-1α) Polymorphisms and Osteonecrosis
por: Chachami, Georgia, et al.
Publicado: (2013)

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth
por: Vindrieux, David, et al.
Publicado: (2014)

HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells
por: Harrison, Hannah, et al.
Publicado: (2018)

Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner
por: Binó, Lucia, et al.
Publicado: (2017)

Pneumococcal infection of respiratory cells exposed to welding fumes; Role of oxidative stress and HIF-1 alpha
por: Grigg, Jonathan, et al.
Publicado: (2017)

HIF2alpha-Associated Pseudohypoxia Promotes Radioresistance in Pheochromocytoma: Insights from 3D Models
por: Seifert, Verena, et al.
Publicado: (2021)

The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI)
por: Kobayashi, Yukino, et al.
Publicado: (2021)

Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha
por: Zhang, Zhenghong, et al.
Publicado: (2023)

Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival
por: Conde, Elisa, et al.
Publicado: (2012)

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis
por: Lange, Clemens, et al.
Publicado: (2016)

The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines
por: Sinnberg, Tobias, et al.
Publicado: (2014)

Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility
por: Taylor, S. E., et al.
Publicado: (2016)

Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia
por: Badawi, Yomna, et al.
Publicado: (2017)

Evaluation of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) in Equine Sarcoid: An Immunohistochemical and Biochemical Study
por: Martano, Manuela, et al.
Publicado: (2020)

Independence of HIF1a and androgen signaling pathways in prostate cancer
por: Tran, Maxine G. B., et al.
Publicado: (2020)

L-Carnitine ameliorates the liver by regulating alpha-SMA, iNOS, HSP90, HIF-1alpha, and RIP1 expressions of CCL4-toxic rats
por: Karabulut, Derya, et al.
Publicado: (2021)

Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function
por: Knowles, Helen J.
Publicado: (2020)

Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization
por: Villacampa, Pilar, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kpa932am1hagk1oblgujse9lfm