Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis

Trytophan Hydroxylase Type I (TPH1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. We have previously described three series of novel, periphery-specific TPH1 inhibitors...

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Detalles Bibliográficos
Autores principales: Cianchetta, Giovanni, Stouch, Terry, Yu, Wangsheng, Shi, Zhi-Cai, Tari, Leslie W., Swanson, Ronald V., Hunter, Michael J, Hoffman, Isaac D., Liu, Qingyun
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885594/
https://www.ncbi.nlm.nih.gov/pubmed/20556201
http://dx.doi.org/10.2174/1875397301004010019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885594/
https://www.ncbi.nlm.nih.gov/pubmed/20556201
http://dx.doi.org/10.2174/1875397301004010019

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