Phosphorylation State-Dependent High Throughput Screening of the c-Met Kinase

High-throughput screening (HTS) of ~50,000 chemical compounds against phosphorylated and unphosphorylated c-Met, a tyrosine kinase receptor for hepatocyte growth factor (HGF), was carried out in order to compare hit rates, hit potencies and also to explore scaffolds that might serve as potential lea...

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Detalles Bibliográficos
Autores principales: Behshad, Elham, Klabe, Ronald M., Margulis, Alexander, Becker-Pasha, Mary, Rupar, Mark J., Collier, Paul, Liu, Phillip C., Hollis, Gregory F., Burn, Timothy C., Wynn, Richard
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885599/
https://www.ncbi.nlm.nih.gov/pubmed/20556206
http://dx.doi.org/10.2174/1875397301004010027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885599/
https://www.ncbi.nlm.nih.gov/pubmed/20556206
http://dx.doi.org/10.2174/1875397301004010027

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