Transposon Tn7 Preferentially Inserts into GAA•TTC Triplet Repeats under Conditions Conducive to Y•R•Y Triplex Formation

BACKGROUND: Expansion of an unstable GAA•TTC repeat in the first intron of the FXN gene causes Friedreich ataxia by reducing frataxin expression. Structure formation by the repeat has been implicated in both frataxin repression and GAA•TTC instability. The GAA•TTC sequence is capable of adopting mul...

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Detalles Bibliográficos
Autores principales: Mancuso, Miriam, Sammarco, Mimi C., Grabczyk, Ed
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886061/
https://www.ncbi.nlm.nih.gov/pubmed/20559546
http://dx.doi.org/10.1371/journal.pone.0011121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886061/
https://www.ncbi.nlm.nih.gov/pubmed/20559546
http://dx.doi.org/10.1371/journal.pone.0011121

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