Cargando…

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm. The identification of compounds that target adu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taldone, Tony, Gillan, Victoria, Sun, Weilin, Rodina, Anna, Patel, Pallav, Maitland, Kirsty, O'Neill, Kerry, Chiosis, Gabriela, Devaney, Eileen
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886105/ https://www.ncbi.nlm.nih.gov/pubmed/20559560 http://dx.doi.org/10.1371/journal.pntd.0000714

Ejemplares similares

A Repurposing Strategy for Hsp90 Inhibitors Demonstrates Their Potency against Filarial Nematodes
por: Gillan, Victoria, et al.
Publicado: (2014)

Attempts to Image the Early Inflammatory Response during Infection with the Lymphatic Filarial Nematode Brugia pahangi in a Mouse Model
por: Myburgh, Elmarie, et al.
Publicado: (2016)

Hsp-90 and the biology of nematodes
por: Him, Nik AIIN, et al.
Publicado: (2009)

Heat shock protein 90 in neurodegenerative diseases
por: Luo, Wenjie, et al.
Publicado: (2010)

Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel
por: Winter, Alan D, et al.
Publicado: (2012)

Emergence of zoonotic Brugia pahangi parasite in Thailand
por: Bhumiratana, Adisak, et al.
Publicado: (2023)

Draft genome of Brugia pahangi: high similarity between B. pahangi and B. malayi
por: Lau, Yee-Ling, et al.
Publicado: (2015)

A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90)
por: Shahinas, Dea, et al.
Publicado: (2013)

Functional genomics of hsp-90 in parasitic and free-living nematodes
por: Gillan, Victoria, et al.
Publicado: (2009)

Cytokine profiles of filarial granulomas in jirds infected with Brugia pahangi
por: Rao, Ramakrishna U, et al.
Publicado: (2006)

Successful Treatment of Brugia pahangi in Naturally Infected Cats with Ivermectin
por: Taweethavonsawat, Piyanan, et al.
Publicado: (2013)

Nearly Complete Genome Sequence of Brugia pahangi FR3
por: Mattick, John, et al.
Publicado: (2020)

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes
por: Taldone, Tony, et al.
Publicado: (2013)

Differential transcript expression between the microfilariae of the filarial nematodes, Brugia malayi and B. pahangi
por: Kariuki, Michael M, et al.
Publicado: (2010)

Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma
por: Thongpiya, Jerapas, et al.
Publicado: (2021)

Complete Genome Sequence of wBp, the Wolbachia Endosymbiont of Brugia pahangi FR3
por: Lebov, Jarrett F., et al.
Publicado: (2020)

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models
por: Hübner, Marc P., et al.
Publicado: (2019)

Reactive Oxygen Species Production and Brugia pahangi Survivorship in Aedes polynesiensis with Artificial Wolbachia Infection Types
por: Andrews, Elizabeth S., et al.
Publicado: (2012)

Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using (89)Zr-DFO-Trastuzumab
por: Holland, Jason P., et al.
Publicado: (2010)

Armigeres subalbatus incriminated as a vector of zoonotic Brugia pahangi filariasis in suburban Kuala Lumpur, Peninsular Malaysia
por: Muslim, Azdayanti, et al.
Publicado: (2013)

Geographic Spatial Distribution Patterns of Dirofilaria immitis and Brugia pahangi Infection in Community Dogs in Chiang Mai, Thailand
por: Kaikuntod, Manusvee, et al.
Publicado: (2020)

Investigation of Armigeres subalbatus, a vector of zoonotic Brugia pahangi filariasis in plantation areas in Suratthani, Southern Thailand
por: Intarapuk, Apiradee, et al.
Publicado: (2021)

Description of potential vectors of zoonotic filarial nematodes, Brugia pahangi, Setaria digitata, and Setaria labiatopapillosa in Thai mosquitoes
por: Siriyasatien, Padet, et al.
Publicado: (2023)

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1
por: Usmani, Saad Z, et al.
Publicado: (2010)

Seasonal distribution and environmental parameters associated with Brugia pahangi and Dirofilaria immitis in naturally infected dogs in Bangkok and vicinity, Thailand
por: Jitsamai, Wanarit, et al.
Publicado: (2021)

Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata
por: Kinnaird, Jane H., et al.
Publicado: (2016)

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species
por: Zong, Hongliang, et al.
Publicado: (2015)

Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
por: Luo, Wenjie, et al.
Publicado: (2008)

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas
por: Calvo-Vidal, M. Nieves, et al.
Publicado: (2021)

Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi
por: Fischer, Chelsea, et al.
Publicado: (2019)

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
por: Kishinevsky, Sarah, et al.
Publicado: (2018)

Rapid Detection and Identification of Wuchereria bancrofti, Brugia malayi, B. pahangi, and Dirofilaria immitis in Mosquito Vectors and Blood Samples by High Resolution Melting Real-Time PCR
por: Thanchomnang, Tongjit, et al.
Publicado: (2013)

Characterisation of infection associated microRNA and protein cargo in extracellular vesicles of Theileria annulata infected leukocytes
por: Gillan, Victoria, et al.
Publicado: (2018)

Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi
por: Bilsland, Elizabeth, et al.
Publicado: (2016)

Physical plasma-triggered ROS induces tumor cell death upon cleavage of HSP90 chaperone
por: Bekeschus, Sander, et al.
Publicado: (2019)

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer
por: Rodina, Anna, et al.
Publicado: (2014)

Hsp90 is a viable therapeutic target in the treatment of KSHV-associated primary effusion lymphoma
por: Nayar, Utthara, et al.
Publicado: (2010)

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70
por: Kang, Yanlong, et al.
Publicado: (2014)

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70
por: Taldone, Tony, et al.
Publicado: (2014)

Selective inhibition of hsp90 paralogs: Structure and binding studies uncover the role of helix 1 in Grp94-selective ligand binding
por: Que, Nanette L. S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0u3n82r5cs8nm5r18h3cfcjdqt