Cargando…

Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection

The vaccinia virus (VACV) N1 protein is an intracellular virulence factor that has a Bcl-2-like structure and inhibits both apoptosis and signalling from the interleukin 1 receptor, leading to nuclear factor kappa B activation. Here, we investigated the immune response to intranasal infection with a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jacobs, Nathalie, Bartlett, Nathan W., Clark, Richard H., Smith, Geoffrey L.
Formato:	Texto
Lenguaje:	English
Publicado:	Society for General Microbiology 2008
Materias:	Animal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886957/ https://www.ncbi.nlm.nih.gov/pubmed/18931086 http://dx.doi.org/10.1099/vir.0.2008/004119-0

Ejemplares similares

Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues
por: Maluquer de Motes, Carlos, et al.
Publicado: (2014)

Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence
por: Ferguson, Brian J., et al.
Publicado: (2013)

Vaccinia virus B5 protein affects the glycosylation, localization and stability of the A34 protein
por: Breiman, Adrien, et al.
Publicado: (2010)

Protein B5 is required on extracellular enveloped vaccinia virus for repulsion of superinfecting virions
por: Doceul, Virginie, et al.
Publicado: (2012)

Transport and stability of the vaccinia virus A34 protein is affected by the A33 protein
por: Breiman, Adrien, et al.
Publicado: (2013)

A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism
por: Mazzon, Michela, et al.
Publicado: (2015)

Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response
por: Froggatt, Graham C., et al.
Publicado: (2007)

Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3
por: Valentine, Robert, et al.
Publicado: (2010)

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein
por: Cooray, Samantha, et al.
Publicado: (2007)

Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence
por: Ember, Stuart W. J., et al.
Publicado: (2012)

Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy
por: Sumner, Rebecca P., et al.
Publicado: (2013)

Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection
por: Benfield, Camilla T. O., et al.
Publicado: (2013)

The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds
por: Gao, William N. D., et al.
Publicado: (2022)

Vaccinia virus strain NYVAC induces substantially lower and qualitatively different human antibody responses compared with strains Lister and Dryvax
por: Midgley, Claire M., et al.
Publicado: (2008)

Adenovirus vector delivery stimulates natural killer cell recognition
por: Tomasec, Peter, et al.
Publicado: (2007)

Optimization of translation enhancing element use to increase protein expression in a vaccinia virus system
por: Richard Jr., Harold B., et al.
Publicado: (2021)

Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence
por: Gubser, Caroline, et al.
Publicado: (2007)

Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection
por: Veyer, David L., et al.
Publicado: (2014)

Acidic residues in the membrane-proximal stalk region of vaccinia virus protein B5 are required for glycosaminoglycan-mediated disruption of the extracellular enveloped virus outer membrane
por: Roberts, Kim L., et al.
Publicado: (2009)

Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112
por: Prod'homme, Virginie, et al.
Publicado: (2010)

Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV
por: Depierreux, Delphine M., et al.
Publicado: (2023)

Lack of Transmission of Vaccinia Virus
por: Stark, James H., et al.
Publicado: (2006)

Murid herpesvirus-4 lacking thymidine kinase reveals route-dependent requirements for host colonization
por: Gill, Michael B., et al.
Publicado: (2009)

Multiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activation
por: Torres, Alice A., et al.
Publicado: (2016)

Evidence for stronger discrimination between conspecific and heterospecific mating partners in sexual vs. asexual female freshwater snails
por: Stork, Sydney, et al.
Publicado: (2022)

Do stronger measures of genomic connectedness enhance prediction accuracies across management units?
por: Yu, Haipeng, et al.
Publicado: (2018)

Vaccinia Virus Protein A49 Is an Unexpected Member of the B-cell Lymphoma (Bcl)-2 Protein Family
por: Neidel, Sarah, et al.
Publicado: (2015)

Stereotyped whistles in southern resident killer whales
por: Souhaut, Marie, et al.
Publicado: (2021)

Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
por: Stack, Julianne, et al.
Publicado: (2005)

Vaccinia and Pox-Virus
por: Chalikonda, Sricharan, et al.
Publicado: (2007)

Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment
por: Castaneda, Diana Cadena, et al.
Publicado: (2018)

The N-terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonism
por: van Knippenberg, Ingeborg, et al.
Publicado: (2010)

An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo
por: Shelton, Holly, et al.
Publicado: (2012)

Treatment with Recombinant Interleukin-15 (IL-15) Increases the Number of T Cells and Natural Killer (NK) Cells and Levels of Interferon-γ (IFN-γ) in a Rat Model of Sepsis
por: Zhao, Xianyuan, et al.
Publicado: (2019)

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival
por: Viant, Charlotte, et al.
Publicado: (2017)

BCL11A Is Oncogenic and Predicts Poor Outcomes in Natural Killer/T-Cell Lymphoma
por: Shi, Hongyun, et al.
Publicado: (2020)

Experimental evidence of chemical attraction in the mutualistic zebra mussel-killer shrimp system
por: Rolla, Matteo, et al.
Publicado: (2019)

Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1
por: Kim, Jinkyung, et al.
Publicado: (2012)

Natural killer cells: role in local tumor growth and metastasis
por: Langers, Inge, et al.
Publicado: (2012)

Expression of Apoptosis‐regulating Proteins Bcl‐2 and Bax in Lymph Node Aspirates from Dogs with Lymphoma
por: Meichner, K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ej9quvhsqr181rgqefg6ar081a