The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

ISG15 is an interferon-induced and antiviral ubiquitin-like protein (Ubl). Herc5, the major E3 enzyme for ISG15, mediates the ISGylation of more than 300 proteins in interferon-stimulated cells. In addressing this broad substrate selectivity of Herc5, we found that: (1) the range of substrates exten...

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Detalles Bibliográficos
Autores principales: Durfee, Larissa A., Lyon, Nancy, Seo, Kyungwoon, Huibregtse, Jon M.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Inc. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887317/
https://www.ncbi.nlm.nih.gov/pubmed/20542004
http://dx.doi.org/10.1016/j.molcel.2010.05.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887317/
https://www.ncbi.nlm.nih.gov/pubmed/20542004
http://dx.doi.org/10.1016/j.molcel.2010.05.002

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