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Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses

Investigating the complex systems dynamics of the aging process requires integration of a broad range of cellular processes describing damage and functional decline co-existing with adaptive and protective regulatory mechanisms. We evolve an integrated generic cell network to represent the connectiv...

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Detalles Bibliográficos
Autores principales: Kriete, Andres, Bosl, William J., Booker, Glenn
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887462/
https://www.ncbi.nlm.nih.gov/pubmed/20585546
http://dx.doi.org/10.1371/journal.pcbi.1000820