Cargando…

The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers

Human chromosome 14q32.2 harbors the germline-derived primary DLK1-MEG3 intergenic differentially methylated region (IG-DMR) and the postfertilization-derived secondary MEG3-DMR, together with multiple imprinted genes. Although previous studies in cases with microdeletions and epimutations affecting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kagami, Masayo, O'Sullivan, Maureen J., Green, Andrew J., Watabe, Yoshiyuki, Arisaka, Osamu, Masawa, Nobuhide, Matsuoka, Kentarou, Fukami, Maki, Matsubara, Keiko, Kato, Fumiko, Ferguson-Smith, Anne C., Ogata, Tsutomu
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887472/ https://www.ncbi.nlm.nih.gov/pubmed/20585555 http://dx.doi.org/10.1371/journal.pgen.1000992

Ejemplares similares

Epimutations of the IG-DMR and the MEG3-DMR at the 14q32.2 imprinted region in two patients with Silver–Russell Syndrome-compatible phenotype
por: Kagami, Masayo, et al.
Publicado: (2015)

Temple syndrome in a patient with variably methylated CpGs at the primary MEG3/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR
por: Kagami, Masayo, et al.
Publicado: (2019)

Corrigendum: Methylation Statuses of H19DMR and KvDMR at WT2 in Wilms Tumors in Taiwan
por: Lu, Meng-Yao, et al.
Publicado: (2022)

Kagami–Ogata syndrome: a clinically recognizable upd(14)pat and related disorder affecting the chromosome 14q32.2 imprinted region
por: Ogata, Tsutomu, et al.
Publicado: (2016)

Genotype-Epigenotype Interaction at the IGF2 DMR
por: Murphy, Susan K., et al.
Publicado: (2015)

Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort
por: Nye, Monica D., et al.
Publicado: (2016)

Deletion of Meg8-DMR Enhances Migration and Invasion of MLTC-1 Depending on the CTCF Binding Sites
por: Han, Xiao, et al.
Publicado: (2022)

Involvement of PGC7 and UHRF1 in the regulation of DNA methylation of the IG-DMR in the imprinted Dlk1-Dio3 locus : PGC7 and UHRF1 regulats IG-DMR methylation
por: Yu, Mengying, et al.
Publicado: (2022)

Identification of the porcine IG-DMR and abnormal imprinting of DLK1-DIO3 in cloned pigs
por: Li, Junliang, et al.
Publicado: (2022)

The 4 Year COBE DMR data is non-Gaussian
por: Ferreira, Pedro G., et al.
Publicado: (1999)

Growing oocyte-specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR
por: Joh, Keiichiro, et al.
Publicado: (2018)

HPG-DHunter: an ultrafast, friendly tool for DMR detection and visualization
por: Fernández, Lisardo, et al.
Publicado: (2020)

Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice
por: Zhang, Liang, et al.
Publicado: (2023)

Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study
por: Masemola, Matshane L., et al.
Publicado: (2015)

Digital PCR improves the quantitation of DMR and the selection of CML candidates to TKIs discontinuation
por: Bernardi, Simona, et al.
Publicado: (2019)

Grapevine DMR6-1 Is a Candidate Gene for Susceptibility to Downy Mildew
por: Pirrello, Carlotta, et al.
Publicado: (2022)

Exploration of hydroxymethylation in Kagami-Ogata syndrome caused by hypermethylation of imprinting control regions
por: Matsubara, Keiko, et al.
Publicado: (2015)

The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus
por: Court, Franck, et al.
Publicado: (2014)

Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain
por: Hara, Satoshi, et al.
Publicado: (2021)

Constitutional and somatic methylation status of DMRH19 and KvDMR in Wilms tumor patients
por: Cardoso, Leila C.A., et al.
Publicado: (2012)

Powdery Mildew Resistance in Tomato by Impairment of SlPMR4 and SlDMR1
por: Huibers, Robin P., et al.
Publicado: (2013)

The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period
por: Matsuzaki, Hitomi, et al.
Publicado: (2023)

Concomitant downregulation of the imprinted genes DLK1 and MEG3 at 14q32.2 by epigenetic mechanisms in urothelial carcinoma
por: Greife, Annemarie, et al.
Publicado: (2014)

Assisted reproductive technology represents a possible risk factor for development of epimutation-mediated imprinting disorders for mothers aged ≥ 30 years
por: Hara-Isono, Kaori, et al.
Publicado: (2020)

Simultaneous observations of CGRO-BATSE gamma-ray bursts with the COBE-DMR differential microwave radiometer
por: Jackson, P D, et al.
Publicado: (1998)

Identification of differentially methylated region (DMR) networks associated with progression of nonalcoholic fatty liver disease
por: Hotta, Kikuko, et al.
Publicado: (2018)

Editing the CsDMR6 gene in citrus results in resistance to the bacterial disease citrus canker
por: Parajuli, Saroj, et al.
Publicado: (2022)

Draft Genome Sequence of Lactiplantibacillus plantarum DMR09, Isolated from Spontaneously Fermented Dahi
por: Tirwa, Ranjan Kaushal, et al.
Publicado: (2023)

Simultaneous editing of two DMR6 genes in grapevine results in reduced susceptibility to downy mildew
por: Giacomelli, Lisa, et al.
Publicado: (2023)

The number of the CTCF binding sites of the H19/IGF2:IG-DMR correlates with DNA methylation and expression imprinting in a humanized mouse model
por: Freschi, Andrea, et al.
Publicado: (2021)

Genome-wide multilocus imprinting disturbance analysis in Temple syndrome and Kagami-Ogata syndrome
por: Kagami, Masayo, et al.
Publicado: (2017)

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes
por: Wallace, Chris, et al.
Publicado: (2009)

Is ZFP57 binding to H19/IGF2:IG-DMR affected in Silver-Russell syndrome?
por: Sparago, Angela, et al.
Publicado: (2018)

Probiotic potential of Lactobacillus plantarum DMR14 for preserving and extending shelf life of fruits and fruit juice
por: Islam, Shirmin, et al.
Publicado: (2023)

DNA Methylation of IGF2DMR and H19 Is Associated with Fetal and Infant Growth: The Generation R Study
por: Bouwland-Both, Marieke I., et al.
Publicado: (2013)

Mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and F. graminearum
por: Brewer, Helen C, et al.
Publicado: (2014)

ZNF445: a homozygous truncating variant in a patient with Temple syndrome and multilocus imprinting disturbance
por: Kagami, Masayo, et al.
Publicado: (2021)

Coffin‐Lowry syndrome in a girl with 46,XX,t(X;11)(p22;p15)dn: Identification of RPS6KA3 disruption by whole genome sequencing
por: Yamoto, Kaori, et al.
Publicado: (2020)

DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2‐DMR0 as a DNA methylation‐dependent, P0 promoter‐specific enhancer
por: Watanabe, Hidetaka, et al.
Publicado: (2019)

Role of Imprinting Disorders in Short Children Born SGA and Silver-Russell Syndrome Spectrum
por: Fuke, Tomoko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_02cshhdgu1kou6q1bv5co1gea3