Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

Targeting of cancer stem cells is believed to be essential for curative therapy of cancers, but supporting evidence is limited. Few selective target genes in cancer stem cells have been identified. Here we identify the arachidonate 5-lipoxygenase (5-LO) gene (Alox5) as a critical regulator for leuke...

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Detalles Bibliográficos
Autores principales: Chen, Yaoyu, Hu, Yiguo, Zhang, Haojian, Peng, Cong, Li, Shaoguang
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887745/
https://www.ncbi.nlm.nih.gov/pubmed/19503090
http://dx.doi.org/10.1038/ng.389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887745/
https://www.ncbi.nlm.nih.gov/pubmed/19503090
http://dx.doi.org/10.1038/ng.389

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