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Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
Targeting of cancer stem cells is believed to be essential for curative therapy of cancers, but supporting evidence is limited. Few selective target genes in cancer stem cells have been identified. Here we identify the arachidonate 5-lipoxygenase (5-LO) gene (Alox5) as a critical regulator for leuke...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887745/ https://www.ncbi.nlm.nih.gov/pubmed/19503090 http://dx.doi.org/10.1038/ng.389 |