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pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking
BACKGROUND: Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part to the difficulty of manipulating large DNA fragments by using conventional molecular cloni...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887845/ https://www.ncbi.nlm.nih.gov/pubmed/20515468 http://dx.doi.org/10.1186/1756-6606-3-17 |