Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

Mitochondrial DNA (mtDNA) mutations accumulate in a number of ageing tissues and are proposed to play a role in the ageing process. We have previously shown that colonic crypt stem cells accumulate somatic mtDNA point mutations during ageing. These mtDNA mutations result in the loss of the activity...

Descripción completa

Detalles Bibliográficos
Autores principales: Greaves, Laura C., Barron, Martin J., Plusa, Stefan, Kirkwood, Thomas B., Mathers, John C., Taylor, Robert W., Turnbull, Doug M.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887930/
https://www.ncbi.nlm.nih.gov/pubmed/20096767
http://dx.doi.org/10.1016/j.exger.2010.01.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887930/
https://www.ncbi.nlm.nih.gov/pubmed/20096767
http://dx.doi.org/10.1016/j.exger.2010.01.013

Ejemplares similares